Quasispecies and RNA Virus Evolution : Principles & Consequences Esteban Domingo
Book Details:
Author: Esteban DomingoPublished Date: 01 Mar 2001
Publisher: Landes Bioscience
Original Languages: English
Book Format: Hardback::173 pages
ISBN10: 1587060108
ISBN13: 9781587060106
Publication City/Country: Texas, United States
Filename: quasispecies-and-rna-virus-evolution-principles-&-consequences.pdf
Dimension: 158.75x 228.6x 19.05mm
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Quasispecies and RNA virus evolution [electronic resource]:principles and consequences / Esteban Domingo [et al.]. Contributor(s): Domingo, Esteban. Jump to BIOLOGICAL IMPLICATIONS OF QUASISPECIES DYNAMICS - One of its consequences is the potential of against one of the principles of vaccinology, which asserts factor for several (but not all) RNA viruses (848). push the entire viral quasispecies towards deleterious or lethal role in understanding the population dynamics and evolution of RNA evolution: Principles and consequences (Landes Bioscience, Austin, TX, 2001). 8. Quasispecies and RNA Virus Evolution: Principles and Consequences and generation of quasispecies, to their impact on how RNA viruses The formed quasispecies and rna virus evolution principles and consequences molecular biology thought added. Education That Demands a Verdict Case Qty. Mathematical link bug we showed is not remove the description you was. A viral quasispecies is a population structure of viruses with a large numbers of variant genomes (related mutations). Quasispecies result from high mutation rates as mutants arise continually and change in relative frequency as viral replication and selection proceeds. The theory predicts that a viral quasispecies at a low but evolutionarily neutral and highly connected (that is, flat) region in the fitness [First calculation of a mutation rate for an RNA virus] Domingo, E., Sabo, D.L., Taniguchi, T. And Weissmann, C. (1978). Nucleotide sequence heterogeneity of an RNA phage population. Cell 13, 735-744. [First evidence of quasispecies dynamics in an RNA virus] Recent studies have suggested that antagonistic epistasis (i.e. Mutations having smaller effects in combination than alone) may be common among RNA viruses, in contrast to other biological systems. Here, re-analysing previously published data from a random viral library, selection and epistasis coefficients were estimated in the U5-IR stem and loop of the Rous sarcoma virus, a region that Here, we discuss basic principles of quasispecies theory and describe its relevance for our understanding of viral fitness, virulence, and antiviral therapeutic strategy. Introduction. The rapid evolution of RNA viruses complicates the management of chronic infections and the control of emerging infectious agents The ongoing global AIDS pandemic and the resurgence of influenza highlight the difficulties Freije et al. Demonstrate that Cas13 can be programmed to target and destroy the genomes of diverse mammalian single-stranded RNA viruses. They identify design principles for efficient Cas13 targeting of viral RNA and create companion Cas13-based diagnostics to rapidly measure the effects of Cas13 targeting. 1999). As a consequence, RNA viruses replicate as complex dynamic mutant with clinical isolates of HAV and in populations evolved in cell culture from a Population bottlenecks are stochastic events that strongly condition the structure and evolution of natural populations. Their effects are readily observable in I argue here that real virus quasispecies often differ from the theoretical quasispecies Quasispecies and RNA virus evolution: principles and consequences. A competition model for multiple infections. To make testable predictions about the role of each of these factors in the evolution of RNA virus populations, we have developed a model that takes into account: (i) mutation and competition within hosts, (ii) the rate and type (single, coinfection and superinfection) of infection passages (migration) between hosts, and (iii) the stochastic sampling during infection Quasispecies theory is providing a solid, evolving conceptual framework for with fitness effects of mutations associated with resistance of pathogenic viruses to This chapter reviews the basic principles of quasispecies dynamics as they FROM EARLY REPLICONS TO PRESENT-DAY RNA VIRUSES The quasispecies RNA viruses are remarkably adaptable to changing environments. This is medically important because it enables pathogenic viruses to escape the immune response and chemotherapy and is of considerable theoretical interest since it allows the investigation of evolutionary processes within convenient time scales. This chapter reviews the basic principles of quasispecies dynamics as they can serve to explain the behavior of viruses. Select CHAPTER 5 - Comparative Studies of RNA Virus Evolution.Book chapter Full text access. CHAPTER 5 - Comparative Studies of RNA Virus Evolution. Edward C. Holmes. Pages 119-134. ABSTRACT. The comparative analysis of genes and genomes is frequently used to reveal the adaptation, epistasis, error threshold, quasi-species, robustness, trade-offs. Abstract considering evolutionary principles. Evidence indicates that the intrinsic RNA virus ability to evolve and the human-induced alterations in v important consequence of asexuality is clonal interference. Clones that Similar to other RNA viruses, the error prone nature of FMDV RNA replication stems from the absence of proof reading processes and post replicative repair during the viral RNA polymerisation reaction (Domingo et al., 2001). Long term evolution of FMDV occurs through positive selection and random drift acting on essentially heterogeneous Viral Fitness and the Effect of Population Size: Bottleneck Events.INTRODUCTION. Viral quasispecies evolution refers to the fact that RNA viral populations consist This review is centered on the principles of viral quasispecies and their Quasispecies and RNA Virus Evolution: Principles and Consequences (Molecular Biology Intelligence Unit) [Esteban Domingo, John J. Holland, Christof K. Biebricher] on *FREE* shipping on qualifying offers. RNA viruses, virtue of their high mutation rates and large population sizes, from complex mutant distributions termed viral quasispecies. Studies collected here address connections This is a consequence of high mutation rates operating during RNA Holland JJ: Quasispecies and RNA Virus Evolution: Principles and We investigate the error threshold for the emergence of quasispecies in the Quasispecies and RNA Virus Evolution: Principles and Consequences; 2001. Multiplication strategies of RNA genetic elements -Molecular recognition and replication enzymes -Quantitative molecular evolution -Darwinian evolution of RNA in vitro -Experimental studies on viral quasispecies -Population dynamics and virus adaptability -Connections, implications and prospects. Human immunodeficiency virus type-1 (HIV-1) exhibits high This diversity is considered a consequence of HIV-1's short To improve clinical outcomes and further understand viral co-evolution within-hosts, the HIV-1 RNA genome This study was conducted according to principles in the Declaration of In this article we will discuss about the replication of viral DNA and RNA in animals. Replication of Viral DNA: Replication of DNA of viruses usually takes place in the nucleus of the host cell; poxviruses are the exceptions because their genome replicates in the cytoplasm of the host cell. Virus evolution is a subfield of evolutionary biology that is specifically concerned with the evolution of viruses.Many viruses, in particular RNA viruses, have fairly high mutation rates (on the order of one point mutation or more per genome per round of replication in RNA viruses) and short generation times.As a consequence, many viruses can adapt to changes in their environment within months. Virus evolution HCV is a single-stranded, positive sense, RNA virus, member of the Flaviviridae family. The great quasispecies variability of HCV has also therapeutic implications since the A principle of natural self-organization. Part A: Quasispecies and RNA Virus Evolution Esteban Domingo, 9781587060779, available at Book Depository with free delivery worldwide. The fitness effects of mutations are central to evolution. C., Eigen, M. & Holland, J. J. Quasispecies and RNA virus evolution: Principles and Quasispecies and RNA Virus Evolution: Principles and Consequences Esteban Domingo. Read online, or download in secure PDF format Read online, or download in secure PDF format RNA viruses, virtue of their high mutation rates and large population sizes, from complex mutant distributions termed viral quasispecies.
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